6q Probe (6q22)

6q Probe (6q22)

Product Description:Lung cancer
Applications: Solid tumors

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Product Details


ROS1 Gene Break Apart Rearrangement Detection Probe



Product Advantages

1.Fleetness: Tissue probe hybridization time: 2 hours. Cell probe hybridization time: 1 hour.

2.Accuracy: Less non-specific background staining (dyeing). Increase difficult samples detection rate.

3.Reproducibility: Different laboratories test results are highly reproducible.

◆Probe Description


ROS1 gene break-apart rearrangement probe uses orange-red dye to mark the ROS1 gene 5' end region and green dye to mark ROS1 gene 3' end region. The ROS1 gene break-apart rearrangement can detect all ROS1 gene rearrangements, avoiding the missed diagnosis caused by a single fusion gene.

◆Detection Significance

ROS1 gene break-apart rearrangement occurs mostly in young, non-smoking lung adenocarcinoma patients. ROS1 rearrangements are different from other mutations such as EGFR, KRAS and ALK. The positive rate of ROS1 rearrangement is about 1.5%, and ROS1 rearrangement positive adenocarcinoma is poorly differentiated. ROS1 break-apart rearrangement positive patients are sensitive to XALKORI (Crizotinib) drugs.

◆Size Specifications


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