BCL2/IGH T (14;18) Fusion Probe
Applications: Hematological tumor
BCL2/IGH t(14;18) gene fusion probe
1.Fleetness: Tissue probe hybridization time: 2 hours. Cell probe hybridization time: 1 hour.
2.Accuracy: Less non-specific background staining (dyeing). Increase difficult samples detection rate.
3.Reproducibility: Different laboratories test results are highly reproducible.
The two probes can be combined with the target detection site ,using an orange-red dye labeled BCL2 gene and a green dye labeled IGH gene.
The t(14;18) translocation occurred in 85% of follicular lymphoma (FL) and 1/3 of diffuse lymphoma (DL) with a poor prognosis. Studies have shown that BCL2/IGH translocation rearrangement plays a role in stimulating B lymphocyte hyperproliferation. The incidence of most translocations in patients with non-Hodgkin's lymphoma is significantly higher than that in healthy controls.