Bladder Cancer Cells Chromosome and Gene Anomaly Probe
Product Description：Bladder cancer
Applications: Solid tumors
Bladder cancer detection probe
1.Fleetness: Tissue probe hybridization time: 2 hours. Cell probe hybridization time: 1 hour.
2.Accuracy: Less non-specific background staining (dyeing). Increase difficult samples detection rate.
3.Reproducibility: Different laboratories test results are highly reproducible.
The bladder cancer probe consists of two sets of probes (see above image). The P16 gene region is marked with orange dye, the centromere region of chromosome 17 (CEP17) is marked with green dye, the centromere region of chromosome 3 (CEP3) is marked with orange dye, and chromosome 7 (CEP7) is marked with green dye. The P16 gene marker region is located at 9p21.3, and the chromosome centromere probe is labeled with a specific alpha satellite sequence.
The most common genetic changes in urinary transitional epithelial cell carcinoma are the loss of chromosome 9 part (such as p16 locus) or the total loss of the epithelial cells in the urinary system. In addition, the development of urinary transitional cell carcinoma is closely related to chromosomal instability and the aneuploidy of chromosomes 3, 7 and 17 in particular. FISH is a non-invasive test that can detect urine exfoliated cells in the patient. If there are two or more abnormal indicators in the above four indicators, or if one of the indicators is complicated, it can be basically defined as urinary transitional epithelial cell carcinoma.