CCND1 (BCL1) Amplification Probe
CCND1(BCL1) gene amplification probe
Tissue probe hybridization time: 2 hours. Cell probe hybridization time: 1 hour.
do not contain Repetitive Sequence result in:
High specificity - Does not bind to non-target fragments .
High sensitivity - Effective detection of small fragments .
Strong fluorescent signal - Not obscured by background color and probe signal .
Fluorescent background and noise are low - Not easy to mask weak signals .
The CCND1 gene amplification probe uses orange-red dye to mark CCND1(BCL1) region, and the green dye to mark the centromeric region of chromosome 11 (CEP 11 ). The CCND1 gene marker region is located in 11q13.3, and the CEP11 probe is labeled with a specific alpha satellite sequence.
CCND1 gene amplification indicates that CCND1 gene plays an important role in tumor development. Patients with CCND1 gene amplification have poor prognosis and are closely related to chemotherapy resistance.