KMT2A (MLL) Break Apart Rearrangement Probe
Product Description: Acute myeloid leukemia/AML(Non APL);acute lymphoblastic leukemia
Applications: Hematological tumor
KMT2A(MLL) gene break probe
1.Fleetness:Tissue probe hybridization time: 2 hours. Cell probe hybridization time: 1 hour.
2.Accuracy:Less non-specific background staining (dyeing). Increase difficult samples detection rate.
3.Reproducibility: Different laboratories test results are highly reproducible.
The MLL gene region was labeled with orange-red dye, and the 3' end of the MLL gene was labeled with green dye. The MLL gene break apart probe was used to detect whether the 11q23 segment was translocated, and all MLL gene rearrangements could be detected, avoiding separate detection. Missed diagnosis caused by a fusion gene.
Common translocation forms of the MLL gene are t(4;11), t(9;11), t(11;19) and other rearrangements. 8-10% of acute myeloid leukemia (AML) has this abnormality. MLL rearrangement exists in 80% of infants with AML, suggesting a moderate risk type; other MLL genes are recombined into high-risk types.