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CBFB Gene Breakthrough Probe
- Aug 15, 2018 -

The CBFB gene breakthrough rearrangement probe is a characteristic chromosomal abnormality of AML, accounting for 5%-10% and 23% of M4 patients in AML patients, usually seen in the AML-M4E0 subtype, while M2, M5 and M4 (no eosinophils) ). It is now believed that the CBFB gene breakthrough rearrangement is a characteristic genetic change of M4E0.


The CBFB gene splitting probe uses the orange-red dye to label the 5' end of the CBFB gene region, the CBFB gene is labeled with a green dye at the 3' end, and the MLL gene splitting probe is used to detect the translocation of the CBFB gene region. 16q22 slices can detect all CBFB gene rearrangements, avoiding missed diagnosis caused by a single fusion gene. Most AML patients with CBFB gene CBFB gene breakthrough rearrangement are sensitive to chemotherapy and have a better prognosis.