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MYB (6q23) Gene Probe Applied To Hematological Tumors
- Aug 15, 2018 -

About the MYB (6q23) gene: The MYB / CEP6 two-color probe was used to detect the deletion of the MYB gene at chromosome 6q23.3. The MYB gene encodes a transcript that is expressed primarily in early lymphocytes and bone marrow cells. Among the different types of lymphoid tumors, 6q aberration is the most common chromosomal variation, and several major deletion regions are located at the long arm end of chromosome 6. One is 6q23. 3-10% of CLL (chronic lymphocytic leukemia) has chromosome structural aberrations at 6q. Absence of MYB is usually accompanied by minor changes. Fluorescence in situ hybridization (FISH) molecular cytogenetics can be used to diagnose and predict CLL because traditional cytogenetic methods are not effective in detecting changes in CLL.

6q deletion abnormality is the fourth most common abnormality of B-CLL, about 10%, 6q deletion has poor prognosis in various tumors including CLL; this probe can detect 2Mb small deletion area, which is karyotype analysis Unable to distinguish.