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FISH probe in molecular cytogenetic diagnostics
- Jan 31, 2019 -

In molecular cytogenetic diagnostics, a profound knowledge on human chromosomes is a necessary prerequisite, i.e., one needs well-trained personnel. The staff has to be able to identify the 24 different human chromosomes on a 300–550 (or higher) haploid band level and recognize alterations. Also for correct interpretation of interphase FISH-based results, knowledge in cytogenetics and heteromorphisms and underlying principles of signal splitting and flaring are necessary

"FISH techniques were originally developed as extra tools in attempts to map genes and a number of advances were achieved with this new technique. However, it soon became apparent that the FISH concept offered promising possibilities also in a number of other areas in biology and its use spread into new areas of research and also into the area of clinical diagnosis. In very general terms the virtues of FISH are in two areas of biology, namely genome characterization and cellular organization, function and diversity. To what extend FISH technology will be further developed and applied in new areas of research in the future remains to be seen.



Reference : Fluorescence In Situ Hybridization (FISH) Thomas Liehr

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Wuhan HealthCare Biotechnology Co., Ltd is a fast growing National High Tech Enterprise (NHTE) and a leading manufacturer engaged in the design, research, development, production and marketing of high standards quality, innovative and affordable molecular cytogenetics product and automation for the benefit of the medical research and medical diagnostics community.

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